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In 1959 scientists caught their first glimpse of a genetic mutation, ‘the Philadelphia chromosome’ and began unraveling the mysterious role it plays in chronic myeloid leukemia (CML) and led to the development of Gleevec, a groundbreaking drug that made this once-fatal cancer treatable with a single daily pill. Jessica Wapner is a freelance science writer, and her new book chronicling the back story behind the breakthrough, “The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level” was released this month.

Millions of people around the world are living with HIV, thanks to drug regimens that suppress the virus. Now there's a new push to eliminate HIV from patients' bodies altogether. That would be a true cure.

We're not there yet. But a report in Science Translational Medicine is an encouraging signpost that scientists may be headed in the right direction.